The targets of the major epilepsy-associated antibodies include the extracellular domains of neuronal proteins such as leucine-rich glioma inactivated-1 (LGI1), contactin-associated protein like 2 (CASPR2), the N-methyl-D-aspartate receptor (NMDAR) and the gamma aminobutyric acid receptor, plus intracellular molecules such as glutamic acid decarboxylase (GAD) [2], [3], [4], [5], [6], [7]. This evidence concerns the gene LGI1 and epilepsy.