For example, Ito et al. demonstrated that ADH1B Arg47His variant was associated with esophageal cancer in Japanese and might be used in personalized prevention programs [27], while Ma et al. did not show significant associations between variations in the ADH1B gene and esophageal squamous cell carcinoma (ESCC) risk in Chinese [28]. This evidence concerns the gene ADH1B and esophageal squamous cell carcinoma.