ALS has been linked to mutations in the gene coding for the superoxide dismutase 1 (SOD1), a protein with an anti-oxidative function localized in the cytosol, the mitochondrial intermembrane space and the nucleus, where it further promotes resistance towards oxidative stress by acting as transcription factor (Tsang et al. 2014). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.