The strongest signal was at rs2854275, G > T, which is localized in the last intron of HLA-DQB1and which is in very strong LD (r2 = 0.95, D’ = 1) with European top HLA marker rs2187668 from HLA-DQA1, was common in both pediatric CD (p = 4.28 × 10−29) and adult CD (p = 5.82 × 10−35). Here, HLA-DQA1 is linked to Cowden disease.