VAV2 and Cowden disease: Similarly, only four Adult CD specific loci, namely VAV2 [vav 2 guanine nucleotide exchange factor], FAM181B [family with sequence similarity 181, member B], non-genic region at 5p15.33, ANK3 [ankyrin 3] and ITLN2 [intelectin 2] were replicated in pediatric CD.