FOXP3 and malignant colon neoplasm: Salama et al. evaluated the distribution of FoxP3+ cells in TLS in stage II colon cancer and described the high density of FoxP3+ cells in TLS as negative prognostic factor of OS (HR 4.22; 95 % CI 1.49–11.91; P = 0.007 in multivariate analysis) [36].