Similarly to what is seen in BCP-ALL, [16, 19] a sigmoid curve was observed for the distribution of CRLF2 expression levels in AIEOP T-ALL patients, with CRLF2 expression at diagnosis ranging from a 0.06- to an 82- fold change with respect to the median value (Figure 1A). Here, CRLF2 is linked to acute lymphoblastic leukemia.