Chen et al have found that overexpressed linc-ROR may decrease the sensibility of 5-FU and paclitaxel with decreased E-cadherin expression, N-cadherin expression, and invasion ability, which may be an important marker for multidrug resistance of breast cancer, and the linc-ROR up-regulation was important for chemotherapy tolerance and invasion of breast cancer [45]. This evidence concerns the gene CDH1 and breast cancer.