To elucidate the oncogenic role of miR-375 in prostate cancer on the cellular level, we focused on the miR-375 target Polycomb repressive complex member CBX7 because it was de-repressed the strongest of the top six validated target genes by miR-375 sponges (factor 1.2, Figure 4F), and because GSA showed the involvement of miR-375 in Polycomb regulation (Supplementary Figure S1). This evidence concerns the gene CBX7 and Familial prostate cancer.