PDK1 and ovarian carcinoma: Ectopic expression of PDK1 and PDK2 enhanced the phosphrylation of PDHE1α and attenuated apoptosis induced by the cotreatment with DCA and Met (Figure 5J, 5K), taken together with the data in Figures 5G-5I, indicating that DCA can sensitize Met through inhibiting PDK/PDH pathway in killing ovarian cancer cells.