SLC7A6, the only other gene found to be positively regulated by both MYCN and TFAP4, is a sodium dependent neutral amino acid transporter belonging to the L-type amino acid transporter (LAT) family, and increased expression of some LAT family members has been shown to be critical for control of protein translation in cancer via the mTORC1 pathway [23]. The gene discussed is MYCN; the disease is cancer.