TFAP4 and colorectal cancer: In this regard, a genome-wide analysis of TFAP4 DNA binding using ChIP-sequencing revealed a similar overall gene distribution pattern for TFAP4- and MYC-binding sites in colorectal cancer [7], suggesting that TFAP4 could be involved in regulation of a large number of genes targeted by MYC in this malignancy, and further supporting the concept of TFAP4 and MYC cooperatively regulating a number of genes in MYC-driven cancers.