When the allelic frequency of the KRAS mutations was normalized for the fraction of neoplastic cells in the six histologic samples, the Heterogeneity Score ranged between 7.33 and 69.33, with a mean value of 28.21 and a median value of 23.62 (Figure 1B), suggesting that in most of the tumor samples of our series the KRAS mutation was sub-clonal. This evidence concerns the gene KRAS and neoplasm.