RAE1 and melanoma: Consistent with the observation, RAE-1 gene-transfection was found resulted in rapid rejection of EL4 (a thymoma), RMA (a T-cell lymphoma) and B16 (a melanoma) cells in syngeneic mice; and 10-fold up-regulated RAE-1 led to less lung metastatic loci from by i.v. transfused B16 cells [11].