The CpG ODN administration up-regulated RAE-1, H60 and MULT-1 on breast cancer cells, H60 and MULT-1 on melanoma cells, and made them only capable of forming dramatically smaller tumors in syngeneic mice, implying that the CpG ODN induced retardation of the tumors by up-regulating NKG2DL. This evidence concerns the gene RAE1 and melanoma.