Liver metastasis tumors had a significantly higher number of Ki-67-positive cells (mean ± standard error of mean, 13.3 ± 3.3%) than bone metastasis (6.2 ± 2.9%) and lung metastasis (4.8 ± 1.4%) tumors, as shown in Table 5 and Figure 6. This evidence concerns the gene MKI67 and bone metastasis.