IGFBP3 and neoplasm: In contrast, tumors from high fat-fed BP3KO mice were not significantly different (WT-chow vs BP3KO-HFD, 650.7 ± 83.1 mg vs 582.5 ± 74.7, p > 0.05, post-hoc Tukey's test), suggesting that the decreased tumor growth associated with the absence of IGFBP-3 is not maintained in the presence of high fat-feeding.