Introduction of miR-7 could decrease the expression levels of EGFR, IGF-1R and CRAF in vitro as well as in VemR A375 melanoma xenograft mice models, which indicated that EGFR, IGF-1R and CRAF were the target genes of miR-7 that are closely associated with the acquired resistance to BRAFi in VemR melanoma. This evidence concerns the gene RAF1 and melanoma.