The results indicated that the activation of PI3K/AKT signaling pathway (increased p-AKT) in parental A375 cells might be an early anti-apoptotic response to BRAF inhibition, which could compensate for the inhibition of MAPK signaling pathway (decreased p-ERK) to maintain the proliferation of parental A375 melanoma cells. The gene discussed is BRAF; the disease is melanoma.