At least part of the effect of CX-4945 on MPNST cell survival is due to its reduction of β-catenin; partial rescue of CX-4945 cytotoxicity was achieved by re-expression of β-catenin using GSK-3β inhibitors, and knockdown of β-catenin phenocopies the apoptosis caused by CK2 inhibition. The gene discussed is GSK3B; the disease is malignant peripheral nerve sheath tumor.