Hypergastrinemia alone was not sufficient to induce metaplastic or dysplastic cells at the SCJ of INS-GAS mice, whereas the addition of hypergastrinemia to the chronic inflammation/BE phenotype led to a marked expansion of Barrett's-like esophagus in L2-IL-1β/INS-GAS mice compared to L2-IL-1β mice (Figure 1G). Here, IL1B is linked to Barrett esophagus.