NR1I2 and malignant colon neoplasm: Since ALDH1A1 appeared as one of the top-ranked differentially regulated genes after PXR up-regulation or inhibition (Supplementary Tables S2&S3) and has been described as key CSC marker [12, 25] and a poor prognosis factor in colon cancer patients [38], we focused our attention on its putative regulation by PXR.