ITIH2 and neoplasm: On the other hand, after UO, oviduct focuses its resources to other functions such as the protection against external agents, up-regulating genes to immune response as IGHA1, ALOX12 and ITIH2, and genes linked to tumour suppression such as LZTS3 and SEMAB3. IGHA1 is a steroid-regulate gene, that participates in antibacterial humoral responses through body fluids, and it may protect the oviduct from external contaminants similar to its function in the cervix [47].