Positive associations with AD severity were found for α‐internexin (P < 2 × 10−6), plectin (P < 0.0007), Ca++/calmodulin‐dependent protein kinase II‐β (P < 0.003), vimentin (P < 0.014), hnRNP A2/B1 (P < 0.02), formin‐like protein 20‐like (P < 0.03), glycogen phosphorylase B (P < 0.04), sequestosome‐1 (P < 0.04), and epiplakin (P < 0.05). The gene discussed is PLEC; the disease is Alzheimer disease.