However, they also bind tau in AD neurofibrillary tangles (Qureshi et al., 2013; Jia et al., 2014), and mutant huntingtin (86Q) in an HD model (Jia et al., 2014), and they have been implicated in aggresome formation (Jia et al., 2014). The gene discussed is HTT; the disease is Huntington disease.