The same points apply to aggregates from AD hippocampus (blue highlighting), but different sets of proteins were most differential between aggregate types: α‐enolase and talins 1 and 2 are >10 times as abundant (56 vs. 5 hits) when associated with Aβ as when linked to tau, while sequestosome‐1 is only found in tau aggregates, and polyubiquitin (UBB) is 3.3 times as abundant there. Here, UBB is linked to Alzheimer disease.