Astrocytic GFAP expression is associated with aging and AD (Middeldorp & Hol, 2011); dominant GFAP mutations in Alexander disease cause protein aggregates that contain GFAP, vimentin, plectin, ubiquitin, and small chaperones such as α‐crystallin (Hagemann et al., 2009). The gene discussed is UBA52; the disease is Alexander disease.