In a similar fashion, we here used C. elegans amyloidopathy models to test the effects of RNA‐interference (RNAi) knockdowns targeting 21 candidate genes that encode proteins orthologous to constituents substantially more abundant in insoluble aggregates from AD than AMC hippocampus, when isolated by affinity to tau‐ or Aβ‐specific antibodies (Tables 1 and 2). This evidence concerns the gene MAPT and Alzheimer disease.