Controls showed a significantly stronger response than IBS patients in the right amygdala during 40 mmHg distention after CRH injection compared with saline injection in ROI analysis (local maximum: x: 34, y: 4, z: -20; t = 3.78, cluster [k] = 34, ROI PFWE-corr = .020) (Fig 2). Here, CRH is linked to irritable bowel syndrome.