TCF7L2 and type 2 diabetes mellitus: For example, a recent genome-wide scan for two-locus interactions in the Wellcome Trust Case Control Consortium T2D GWAS data did not reveal any significant epistatic signals at a Bonferroni-corrected p-value threshold of 2.14x10-11 after adjusting for the main effects of the most strongly associated T2D locus, TCF7L2 [41].