To investigate the clinical significance of the upregulation of NSUN2 in breast cancer, we analyzed the potential associations between NSUN2 expression and the clinical characteristics of paraffin-embedded breast cancer tissue specimens obtained from 191 patients, including 41 (21.5%) stage I cases, 78 (40.8%) stage II cases, 60 (31.4%) stage III patients, and 12 (6.3%) stage IV cases. Here, NSUN2 is linked to breast carcinoma.