BRCA1 and breast carcinoma: Telli et al reported that the combination of gemcitabine, carboplatin, and iniparib as NAC in early stage breast cancer resulted in a pCR rate of 33% in wild type BRCA1/2, 47% in BRCA1/2 mutation carriers, and 56% in BRCA1/2 mutation carriers with TNBC [15].