In a Ptpn11-mutated animal model that recapitulates a myeloproliferative condition resembling JMML [25], we found STAT5b mRNA and Stat5 protein upregulation together with miR-150-5p downregulation in whole BM cells, splenocytes and c-kit+ cells. The gene discussed is PTPN11; the disease is juvenile myelomonocytic leukemia.