In a Ptpn11-mutated animal model that recapitulates a myeloproliferative condition resembling JMML [25], we found STAT5b mRNA and Stat5 protein upregulation together with miR-150-5p downregulation in whole BM cells, splenocytes and c-kit+ cells. This evidence concerns the gene KIT and juvenile myelomonocytic leukemia.