ESR1 and breast cancer: To further identify the role of CTMP in different breast cancer subgroups, including Luminal A (ER+/HER2-), Luminal B (ER+/HER2+), HER2-enriched (HER2+/ER-) and TNBC (ER-/Her2-/PR-), the association between CTMP expression level and OS or DFS were analyzed by Kaplan-Meier analysis (Figure 2A).