DAPK1 and Stroke: Recently, Pei et al. found that activated DAPK1 phosphorylates p53 at serine-23 (pS23) via a direct binding of DAPK1 death domain (DAPK1DD) to the DNA-binding motif of p53 (p53DM), converging the signaling point of necrotic and apoptotic pathways in stroke [53].