BRAF and melanoma: In our patient, after six weeks of treatment with BRAF/MEKi, an increase in CD8+ PD-L1+ lymphocyte infiltration was found at the cutaneous primary melanoma in complete regression (Figure 3D-3F), whereas there was no infiltration by CD8+ cells on bone metastases biopsy performed two weeks after starting BRAF/MEKi (Figure 3A-3C).