FLT3 and acute myeloid leukemia: Interestingly, FLT3-ITD positive cell lines, such as MV4-11, MOLM-13, and MOLM-14, and FLT3-ITD positive primary AML cells are much more sensitive to PI3KD/V-IN-01 inhibition than wt FLT3 AML cell lines and primagrafts.