PIK3C3 and B-cell chronic lymphocytic leukemia: Interestingly, Vps34-IN-1 itself showed micro molar potencies against most of cell lines, including two CLL cell lines (HS505T and MEC-1), the latter of which poorly responded to CAL-101, GDC-0941 and PI3KD/V-IN-01 (GI50: >10 μM).