(Figure 3A) For MV4-11 cells (AML), 3.3 μM of Vps34-IN-1(treatment with which leads to 43.5% inhibition of cell growth/viability) and 1.1 μM of CAL-101 (treatment with which leads to 62.4% inhibition of cell growth/viability) could together synergistically lead to 16.7% inhibition. Here, PIK3C3 is linked to acute myeloid leukemia.