FLT3 and acute myeloid leukemia: Given that FLT3-ITD-positive MV4-11 cells and FLT3-ITD-positive primary AML cells were observed to be especially sensitive to PI3KD/V-IN-01 (see Table 1), we decided to investigate the in vivo effects of PI3KD/V-IN-01 using an in vivo model of mutant FLT3-positive leukemia.