Given the possible protective effects of autophagy induced by PI3Kδ inhibition and the structural similarity between PI3Kδ (Class I PI3K) and Vps34 (Class III PI3K), we postulated that development of a selective PI3Kδ and Vps34 dual inhibitor might enhance the cytotoxic effect of PI3Kδ inhibition on B-cell malignances, such as CLL and AML. The gene discussed is PIK3C3; the disease is acute myeloid leukemia.