AGTR1 and hypertensive disorder: To investigate whether other receptors for Ang II or its metabolites play a role in Ang II-stimulated hormone secretion from the colon, we performed secretion experiments in the presence of Candesartan cilexetil, a prodrug used to treat hypertension, which is converted to the selective AT1 inhibitor Candesartan by the intestinal wall esterases (21).