These cells express lytic proteins, including vIL-6, vGPCR, and K1, and ultimately upregulate the expression of cellular inflammatory and angiogenic cytokines [250], including VEGF [251], IL-6, CXCL8 and bFGF, which play important roles in KS development in a paracrine fashion. The gene discussed is CXCL8; the disease is Kaposi's sarcoma.