In addition, KSHV manipulates the host glycoproteins initiating the ensuing angiogenic pathways, as observed in the role played by extracellular matrix metalloproteinase inducer (EMMPRIN), a membrane-associated glycoprotein, which increases the expression of VEGF-A during the infection of endothelial cells with KSHV, leading to cellular invasiveness by regulating PI3 kinase and mitogen-activated protein kinases (MAPK) pathways [17,74]. Here, VEGFA is linked to infection.