They reported lower expression of miR-146 in pancreatic cancer cells than in normal human pancreatic duct epithelial cells and found that re-expression of miR-146a subdued malignancy by downregulating EGFR, NF-κB, IRAK-1, interleukin-1 receptor-associated kinase 1 (IκBα), and metastasis associated 1 family member 2 (MTA-2) [86]. Here, IRAK1 is linked to familial pancreatic carcinoma.