The result showed that FGF19 expression appeared to increase significantly with the histological severity of liver disease, showing a trend of FGF19 expression in specimens with ST (224.13 ± 115.68, p = 0.087), NASH (413.99 ± 159.55, p = 0.002), CR (613.35 ± 157.29, p < 0.0001) and HCC (2507.28 ± 831.10, p = 0.0001) as compared with the paired peritumoral tissues (142.96 ± 41.32). Here, FGF19 is linked to hepatocellular carcinoma.