In breast cancer patients, marked LFA-1 expression was evident within and around brain metastasis foci (Figure 2A–2B) whilst ICAM-1 was found predominantly around the micro-metastasis with a more widespread pattern (Figure 2C); as for the mouse models, expression of LFA-1 appeared to primarily co-localise with tumour cells (Figure 2D–2E), and ICAM-1 seemed to be expressed in more brain cell types (Figure 2F). This evidence concerns the gene ITGAL and breast cancer.