ITGAL and neoplasm: In animals injected with LFA-1 knockdown tumour cells, the levels of COX-2 were significantly reduced in astrocytes (~80% reduction; Figure 5E, 5I), neurons (~65% reduction; Figure 5F, 5I) and endothelial cells (~60% reduction; Figure 5G, 5I) compared to animals injected with the parent MDA231Br-GFP cells.