Previous studies have suggested that ZKSCAN3 directly or indirectly regulates the expression of various genes, such as CCND1, CCND2, EGFR, IGF-2, integrin-β4, NF-κB, and VEGF [6–8], all of which are known to involve tumorigenesis, tumor progression, and/or metastasis. The gene discussed is NFKB1; the disease is neoplasm.