HIF1A and acute myeloid leukemia: To corroborate the findings obtained with HIF-1α chronic silencing, and to establish whether more pronounced and acute inhibition of HIF-1α may further impinge on the functions of AML-M5 leukemic cells, we next used the RNA antagonist EZN-2968, a locked nucleic acid-modified oligonucleotide (LNA-ON) targeting HIF-1α, and its control LNA-ON EZN-3088 [50].