More specifically, genetic deletion of Hif-1α before leukemia initiation by different AML oncogenic mutations (AML1-ETO, MLL-AF9, HOXA9/MEIS1) revealed that loss of Hif-1α expression did not delay leukemia initiation or progression in any of the genetic models tested, and, contrary to previous data, its deletion either did not regulate or rather increased leukemia self-renewal in secondary transplantation experiments [26]. This evidence concerns the gene KMT2A and acute myeloid leukemia.