Interestingly, we did not find any up-regulation of the AML-M5 hypoxia sub-signature in M5 leukemic blasts when compared to normal monocytes, thus suggesting that up-regulation of this specific HIF-1α sub-signature may be a feature of monocytes, which is amplified in a leukemic setting (data not shown). This evidence concerns the gene HIF1A and acute myeloid leukemia.