To understand whether HIF-1α inhibition led to impaired leukemia development and progression in vivo we took advantage of a MOLM-13 xenograft model of acute monocytic leukemia that mimics human leukemia in that mice develop a rapid and fatal acute myeloid leukemia localizing to the bone marrow, spleen and peripheral blood upon intravenous injections [51]. This evidence concerns the gene HIF1A and leukemia.