HIF1A and acute myeloid leukemia: With our current work, by undertaking an in silico approach aimed to identify AML patients with deregulated hypoxia signaling, we found that besides AML-M3, where we had previously implicated HIF factors [24, 28, 29], patients with the M5 sub-type of AML also show significant up-regulation of HIF-1α-target genes as compared to all other AML sub-types.