Amongst different AML, the FAB sub-type that was most significantly discriminated by Prediction Analysis of Microarray (PAM) was AML-M3, with a sensitivity of 0.800 and an accuracy of 0.964, thus confirming our previous results about the involvement of HIF-1α in APL [24–28]. The gene discussed is HIF1A; the disease is acute promyelocytic leukemia.