These studies reveal that SF can promote cancer cell proliferation by inducing the expression of angiogenic genes and pleotropic proinflammatory cytokines/chemokines via the activation of pathways including COX-PGs, EGFR-ERK 1/2, NF-κB, and EP2-EGFR-PI3kinase-AKT pathways [89, 108–110]. Here, EGFR is linked to cancer.