Furthermore, NAR could decrease the blood glucose level in STZ induced diabetic rats [13, 14], suppress macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity [15], and inhibit production of IL-1β, IL-6, type IV collagen, fibronectin, TGF-β1, and monocyte chemoattractant protein-1 (MCP-1) in the kidney of diabetic mice [16]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.