Research showed NAR decreased cell invasion and metastasis by inhibition of TGF-β1/smads signaling pathway in pancreatic cancer, and NAR also reduced TGF-β1-induced hepatic satellite cell extracellular matrix deposition by inhibiting TGF-β1/smads signals [12, 40]. The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.