Allele gene T of SNP rs974456 of STRA6 gene was significantly associated with T2DM under the dominant genetic model when FDR was used (OR = 0.73, 95% CI: 0.57–0.94, P = 0.048), but not under the additive genetic model and recessive genetic model, which suggested that people that had allele gene T could significantly reduce the risk of T2DM (P > 0.05). Here, STRA6 is linked to type 2 diabetes mellitus.