Since, variation in AKT1—one of the three genes encoding Akt—has been associated with schizophrenia and bipolar disorders (Ikeda et al., 2004; Karege et al., 2012), PI3K/Akt activation by adropin might also have a therapeutic potential in disorders such as Parkinson's (Burke, 2007; Timmons et al., 2009) and schizophrenia (Schwab et al., 2005) as discussed below:. Here, AKT1 is linked to schizophrenia.