Recent reports have also shown inhibitory effect of ESE-1 on stem cell transcription factor Oct4 expression by binding to EBS in the conserved region 2 (CR2) of the Oct4 promoter during retinoic acid (RA)-induced differentiation of human embryonic carcinoma cell line NCCIT (Park et al., 2014). Here, POU5F1 is linked to embryonal carcinoma.