NFKB1 and amyotrophic lateral sclerosis: In addition, inhibition of an upstream activator of the NFκB pathway, Rho kinase, with Fasudil modulates microglial activation, reduces microglial infiltration to the spinal cord and improves functional outcome in the SOD1 mutant mouse model of amyotrophic lateral sclerosis (ALS) (Tonges et al., 2014).