As well, the first case of familial retinoblastoma (Rb) caused by a de novo insertion of a full-length L1 into intron 14 of the Rb gene, resulting in the aberrant and non-canonical mRNA splicing of the Rb gene, was reported (Rodríguez-Martín et al., 2016). The gene discussed is RB1; the disease is Familial retinoblastoma.