Additional examples of tumor suppressor genes whose mechanisms of action involve transcriptional suppression of the IGF1R gene are the von-Hippel–Lindau (VHL) protein, a gene with important roles in the etiology of renal cancer (102), and WT1, a zinc-finger tumor suppressor with key roles in Wilm’s tumor, or nephroblastoma (103, 104). This evidence concerns the gene VHL and Wilms tumor.