IGF1R and neoplasm: Regarding the impact of IGF1R subcellular distribution on tumor phenotype and responsiveness to IGF1R-directed therapies, Aleksic et al. (111) reported the presence of nuclear IGF1R in primary renal cancer cells, formalin-fixed tumors, preinvasive lesions of the breast, and rapidly proliferating non-malignant tissues, and they also demonstrated that nuclear IGF1R was associated with poor prognosis in renal cancer.