TGFB1 and lung carcinoma: A follow-up study from the same group showed that not only the onfFN is capable, by itself, of inducing EMT in lung cancer cells but it also presents a synergism with TGF-β1, leading to the belief that cells undergoing the transition may secrete onfFN, which once incorporated to the cellular matrix may facilitate the process to other cells exposed to lesser concentrations of TGF-β1 (20).