In this regard, employment of reagents such as PS100, GFAP, epithelial membrane antigen (EMA), cytokeratin-18 (CK-18), progesterone receptors (PR), and vimentin should be useful to guide diagnosis: for instance, diffuse EMA, CK18, PR, and vimentin immunolabeling is akin to meningiomas while PS100, GFAP, and ring/dot-like EMA positivity is seen in ependymomas. This evidence concerns the gene GFAP and ependymoma.