VEGFA and neoplasm: Besides, it inhibited the migration and tube formation, reduced secreted level of vascular endothelial growth factor (VEGF), and increased the secreted level of pigment epithelium-derived factor (PEDF) at noncytotoxic concentrations. In vivo experimental results revealed that CK effectively disrupted bFGF-induced neovascularization in the Matrigel plugs excised from mice and inhibited the tumor formation of SGC7901 cells in nude mice [42, 68].