Oral administration of CK significantly inhibited the tumor proliferation at the implantation site after intrapulmonary implantation of Lewis lung carcinoma and colon 26-L5 tumor cells in concentration- and time-dependent manners and suppressed the metastasis to meditational lymph nodes, which was primarily due to induce caspase-3-dependent apoptosis [38]. This evidence concerns the gene CASP3 and neoplasm.