However, in papillary thyroid cancer (PTC), tissue MK overexpression has been reported to be in correlation with clinicopathological features of the tumor, hypothesizing that MK might play a role as a biomarker for diagnosis and more aggressive behavior of papillary thyroid cancer such as lymph node metastasis and extrathyroidal invasion [4, 21]. The gene discussed is MDK; the disease is neoplasm.