Since MPT0E014 only minimally reduces blood glucose level, the significant reductions in myocardial TNF-α and IL-6 proteins in MPT0E014-treated DM rats suggest that the HDAC inhibitor, MPT0E014, may serve as an anti-inflammatory agent for DM cardiomyopathy independent of glucose control at least in part. Here, HDAC9 is linked to diabetes mellitus.