DNMT1 and autosomal dominant cerebellar ataxia: Mutations in the TS domain of DNMT1 cause neurodegeneration like hereditary sensory autonomic neuropathy with dementia and hearing loss (HSAN1E; Klein et al., 2011) and autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN; Winkelmann et al., 2012).