MECP2 and nervous system disorder: In addition to RTT, Mecp2 was implicated in other neurological diseases, including Hirschsprung’s disease, autism spectrum disorder, schizophrenia, Prader-Willi, and Angelman syndromes (Carney et al., 2003; Shibayama et al., 2004; Nagarajan et al., 2006; Loat et al., 2008; Ramocki et al., 2009; Zhou et al., 2013).